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Session 2 — Epigenetic-based prevention and early detection of tumorigenesis in high-risk populations

Series: 2026 SITC Computational IO Series, session 2 of 10 Date: June 9, 2026, 1:00–2:00 p.m. ET Moderator: Brian Piening, PhD — Earle A. Chiles Research Institute Faculty: Christoph Bock, PhD — CeMM Research Center for Molecular Medicine & Medical University of Vienna Recording: SITC OnDemand (registrant / member access) Status: Delivered · content pending recording access

What the session covers

Epigenetic readouts — DNA methylation and chromatin state — applied to prevention and early detection in populations at elevated cancer risk, rather than to established tumors. The single-faculty, 60-minute format is the series' standard deep-dive shape.

Bock's group is a long-standing methods source in epigenomics and single-cell multi-omics, so the talk is likely to be as much about assay and analysis design as about a specific cohort result. Inferred from the speaker's field, not stated by SITC — confirm against the recording.

Why it matters to this corpus

  • The clearest statement of the series' 2026 framing — immunoprevention and immune interception in high-risk cohorts, an axis with no existing coverage in this corpus.
  • Epigenomics methods overlap the chromatin and sequence-to-function material in SCGD26 and the AACR bioinfo-tools topic.
  • Risk-stratification design is structurally the same problem as the biomarker-stratifier work elsewhere in the corpus: define a high-risk population, find a molecular readout that moves treatment or surveillance.
  • Pairs directly with session 3 (immune-based early detection) and session 10 (pre-cancer atlas).

Open items

  • [ ] Obtain OnDemand recording; capture the talk title, cohorts, and assays presented.
  • [ ] Link the specific methods and papers cited.

Sources