Theme — clinical

Items in corpus: 35

Papers

• Real-world RNA-seq integration — Han et al., bioRxiv, 2026
  Industry-authored — deployment-grade robustness gaps.
• Deep deterministic UQ — van Amersfoort et al., 2024
  Uncertainty-quantification method for the clinical-grade-FM track.
• Conformal prediction — Angelopoulos & Bates, 2023
  Distribution-free uncertainty paired with the UQ track.
• Digital twins of ex vivo human lungs for personalised therapeutic-efficacy evaluation — Zhou et al., Nature Biotechnology, 2026
  Virtual-organ agenda — personalised organ-scale simulation on real lungs.
• UNI for EGFR mutation detection in clinical trial — Janowczyk et al., Nature Medicine, 2025
  First deployment-grade clinical FM paper (197 patients, 43% testing avoidance).
• CancerFoundation — bioRxiv, 2024
  Cancer-domain-specific single-cell FM.
• Sukumaran et al. — clinical-decision-support evaluation — JCO Precision Oncology, 2025
  Framework for clinical AI evaluation.
• UNAGI — generative model for cellular dynamics + in-silico drug discovery — Ding lab et al., Nature Biomedical Engineering, 2025
  Time-series scRNA generative model used as a virtual-disease simulator for in-silico perturbation screens.
• DeepRare — agentic system for rare-disease diagnosis with traceable reasoning — Zhao et al., Nature, 2026
  Multi-agent LLM diagnosis system that outperformed physicians on rare-disease cases — the agentic-clinical proof point.
• HEX — virtual spatial proteomics from histopathology for lung-cancer biomarkers — Xiang et al., Nature Medicine, 2026
  H&E → 40-protein spatial proteomics; +22% prognostic, +24-39% immunotherapy-response prediction across 2298 NSCLC patients.
• Multimodal clocks of human aging — Guang-Hui Liu et al., Cell, 2026
  mCAS cohort (2019 individuals) → core-capacity / multimodal / organ-specific aging clocks; MAE 3.87y on chronological age.
• KEEP — knowledge-enhanced pathology vision-language foundation model — MAGIC-AI4Med (SJTU + Shanghai AI Lab), Cancer Cell, 2025
  Knowledge-graph-conditioned pathology VLM from Shanghai Jiao Tong — Chinese answer to PathChat/Virchow.
• MERCI — mitochondrial-receiver cell detection in tumours — Cell Metabolism
  Computational method spotting cells with mitochondrial-transfer signatures — used as motivation in AIVM commentary.

Tools

• MedAgentGym
  Agentic environment / benchmark for training and evaluating medical AI agents.
• PathChat-DX — Mahmood Lab, 2025
  First generative-AI pathology tool with FDA Breakthrough Designation (Jan 2025).
• CHIEF
  Pathology FM for cancer detection and prognosis across tissue types.
• Prov-GigaPath — Microsoft + Providence
  Whole-slide pathology FM trained on real-world clinical slides.
• Med-Gemini — Google
  Google's medical multimodal model family for clinical reasoning and image Q&A.
• Owkin Pathology Explorer in Claude — Owkin, 2026
  Agent using pathology FMs inside Claude's clinical workflow — production agent-using-FM example.

Benchmarks

• Campanella et al. clinical-grade pathology panel — Campanella et al., Nature Communications, 2025
  Multi-task pathology benchmark for FM evaluation.

Organisations

• IBS — Park Jong-eun (human digital twin) — Institute for Basic Science, Korea
  Korean national lab investing in human-digital-twin programme around single-cell data.
• Paige.AI + MSK — Thomas Fuchs
  First FDA 510(k)-cleared general-purpose pathology AI (Jan 2025); Virchow line.
• Owkin (Paris / NYC)
  Only major industrial pathology player shipping open weights (Phikon, Apache-2.0).
• PathAI
  Clinical-AI vendor for pathology.
• Tempus AI
  Multimodal clinical AI; IPO June 2024.
• Aignostics
  AI pathology vendor.
• Proscia
  Digital pathology platform.
• Roche Tissue Diagnostics
  Pharma pathology AI division.

Commentary

• From equations to agents — the AI virtual cell reshaping precision oncology — The Innovation Oncology (perspective), 2026
  Clinical-oncology framing of the AIVC story.
• From data chaos to precision medicine — Schönhuth, Nature Machine Intelligence, 2025
  Short framing commentary on the data-to-clinic gap.
• Eric Topol's Substack — biomedical AI — Substack
  Clinical-AI perspective from a cardiologist.

Move

• Merck + Mayo Clinic collaboration — 2026
  Feb 2026 collaboration — pharma + clinical data axis around AI models.
• Noetik + GSK collaboration — 2026
  Noetik (spatial-omics AIVC startup) lands a GSK deal.
• JPM 2026 — Lilly + NVIDIA $1B AI Co-Innovation Lab — 2026
  Largest pharma–AI infrastructure commitment, JPM Day 1.
• PathChat-DX FDA Breakthrough Designation — 2025
  First generative-AI pathology tool to win FDA Breakthrough.

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Regenerated 2026-05-15 from a 277-item corpus by resourcelib-views.