Theme — pathology

Items in corpus: 35

Papers

• Hibou-LP SAE — arXiv, 2024
  First pathology-FM sparse autoencoder.
• UNI for EGFR mutation detection in clinical trial — Janowczyk et al., Nature Medicine, 2025
  First deployment-grade clinical FM paper (197 patients, 43% testing avoidance).
• HEX — virtual spatial proteomics from histopathology for lung-cancer biomarkers — Xiang et al., Nature Medicine, 2026
  H&E → 40-protein spatial proteomics; +22% prognostic, +24-39% immunotherapy-response prediction across 2298 NSCLC patients.
• KEEP — knowledge-enhanced pathology vision-language foundation model — MAGIC-AI4Med (SJTU + Shanghai AI Lab), Cancer Cell, 2025
  Knowledge-graph-conditioned pathology VLM from Shanghai Jiao Tong — Chinese answer to PathChat/Virchow.

Tools

• PathChat-DX — Mahmood Lab, 2025
  First generative-AI pathology tool with FDA Breakthrough Designation (Jan 2025).
• UNI — Nature Medicine, 2024
  Original Mahmood-lab pathology tile encoder.
• UNI2-h — Mahmood Lab, 2025
  Mahmood-stack flagship tile encoder (681M); HF-gated since Jan 2025.
• Virchow2 / Virchow2G — Zimmermann et al. (Paige + MSK), arXiv, 2024
  Current pathology-FM SOTA and most hardware-transparent; 632M ViT-H/14 on ~2B tiles / ~225k patients.
• CHIEF
  Pathology FM for cancer detection and prognosis across tissue types.
• Prov-GigaPath — Microsoft + Providence
  Whole-slide pathology FM trained on real-world clinical slides.
• Phikon / Phikon-v2 — Owkin
  Owkin's pathology FMs; notable as Apache-2.0 exceptions in a license-restrictive family.
• H-optimus-0 — Bioptimus
  Open-weights pathology tile encoder; permissive-license exception.
• Hibou
  Open pathology FM (Apache-2.0).
• CONCH — Mahmood Lab
  Contrastive vision-language pathology FM.
• TITAN — Mahmood Lab
  Slide-level model on top of the UNI2-h tile encoder.
• PathChat / PathChat-2 / PathChat-DX — Nature, 2024
  Mahmood vision-language pathology assistant; DX got FDA Breakthrough.
• mSTAR — multimodal spatial-transcriptomics aggregation FM — Xu et al., Nature Communications, 2025
  Spatial pathology FM aggregating ST + WSI signals.
• GPFM — Gigapixel Pathology Foundation Model — Ma et al., Nature Biomedical Engineering, 2026
  Large-scale gigapixel pathology FM.
• PathPT — pathology transformer — Nature Communications, 2026
  Pathology FM variant in the 2026 wave.
• PathOrchestra — ensemble pathology FM — Yan et al., npj Digital Medicine, 2025
  Ensemble approach across pathology FMs.
• PathChat-2 — Mahmood Lab, 2026
  Successor instruction-tuned pathology assistant (>1M pairs).
• Owkin Pathology Explorer in Claude — Owkin, 2026
  Agent using pathology FMs inside Claude's clinical workflow — production agent-using-FM example.

Benchmarks

• Campanella et al. clinical-grade pathology panel — Campanella et al., Nature Communications, 2025
  Multi-task pathology benchmark for FM evaluation.

Datasets

• HEST-1k
  Histology-with-spatial-transcriptomics benchmark dataset.

Organisations

• Mahmood Lab (Harvard / BWH / MGB) — Faisal Mahmood
  Full pathology vertical stack: UNI → TITAN → CONCH → PathChat; PathChat-DX FDA Breakthrough.
• Paige.AI + MSK — Thomas Fuchs
  First FDA 510(k)-cleared general-purpose pathology AI (Jan 2025); Virchow line.
• Owkin (Paris / NYC)
  Only major industrial pathology player shipping open weights (Phikon, Apache-2.0).
• PathAI
  Clinical-AI vendor for pathology.
• Aignostics
  AI pathology vendor.
• Proscia
  Digital pathology platform.
• Modella AI
  Acquired by AstraZeneca for pathology FM stack (JPM 2026).
• Roche Tissue Diagnostics
  Pharma pathology AI division.

People

• Faisal Mahmood — Harvard
  UNI, CONCH, PathChat, TITAN — most complete vertical pathology stack.

Move

• JPM 2026 — AstraZeneca acquires Modella AI — 2026
  First big-pharma acquisition of an AI-FM firm.
• PathChat-DX FDA Breakthrough Designation — 2025
  First generative-AI pathology tool to win FDA Breakthrough.

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Regenerated 2026-05-15 from a 277-item corpus by resourcelib-views.